杰西•詹姆斯（Brad Pitt 布莱德•彼特 饰），南北战争时期最著名的强盗，他与兄长组建的詹姆斯帮伙同其喽罗犯下无数宗抢劫案，即使防卫再出色的银行也难逃他们的魔掌。杰西凭借其出神入化的枪法和经历成为平民百姓心中的传奇人物。
　　人过中年杰西逐渐厌倦颠沛流离和与政府捉迷藏的生活，手下的喽罗或死或伤，兄长也因杰西的坏脾气选择离开。新加入“詹姆斯帮” 的懦弱男孩罗伯特•福特（Casey Affleck 凯西•阿弗莱克 饰）视杰西为超级偶像，与渐感疲惫的杰西隐居乡间。然而经过多年的相处，罗伯特却最终成为这名传奇侠盗生命之闸的掣动者……

　　Beginning just after the bloody Sioux victory over General Custer at Little Big Horn, Bury My Heart at Wounded Knee intertwines the perspectives of three characters: Charles Eastman (Beach), né Ohiyesa, a young, Dartmouth-educated, Sioux doctor held up as living proof of the alleged success of assimilation; Sitting Bull (Schellenberg), the proud Lakota chief who refuses to submit to U.S. government policies designed to strip his people of their identity, their dignity and their sacred land – the gold-laden Black Hills of the Dakotas; and Senator Henry Dawes (Quinn), who was one of the architects of the government policy on Indian affairs. While Eastman and patrician schoolteacher Elaine Goodale (Paquin) work to improve life for the Indians on the reservation, Senator Dawes lobbies President Grant (Thompson) for more humane treatment, opposing the bellicose stance of General William Tecumseh Sherman (Feore). Hope rises for the Indians in the form of the prophet Wovoka (Studi) and the Ghost Dance – a messianic movement that promises an end of their suffering under the white man. This hope is obliterated after the assassination of Sitting Bull and the massacre of hundreds of Indian men, women and children by the 7th Cavalry at Wounded Knee Creek on Dec. 29, 1890. Written by HBO Films